Current approaches to quality assessment, non-clinical and clinical studies of dendritic cell vaccines in oncology

At present, personalised cellular immunotherapy is considered a promising approach to the treatment of malignant neoplasms. The effectiveness these methods evaluated in context clinical and biological tumour characteristics state immune system particular patient. One options for cancer development autologous dendritic cell vaccines. aim this study was analyse current methodological approaches evaluation quality, efficacy, safety This review describes functional role cells response regulation. paper presents results literature analysis covering obtaining vaccines with specific characteristics, quality assessment, studies anti-tumour efficacy therapy products, experience conducting non-clinical studies. highlights aspects international registration use products. authors discuss vaccines, which should obtain information select dose, route, mode administration identify immunological markers correlating covers trials various propose list attributes human somatic cell-based medicinal products further use.